TY  -  
T1  - Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation 
SN  -  /  
UR  - http://hdl.handle.net/10138/316315 
T3  -  
A1  - Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M; Ylä-Herttuala, Seppo; Turunen, Tiia A; Turunen, Mikko P; Koistinaho, Jari; Malm, Tarja 
A2  -  
PB  - BioMed Central 
Y1  - 2020 
LA  -  
AB  - Abstract

Background
Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited secondary to the ischemic attack further aggravate the stroke-induced neuronal damage. It has been demonstrated that these responses are regulated at the level of non-co... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Stroke; Neuroinflammation; MicroRNAs; Microglia/macrophage activation; Functional improvement 
N1  -   
PP  -  
ER  -