TY  -  
T1  - Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial 
SN  -  /  
UR  - http://hdl.handle.net/10138/299162 
T3  -  
A1  - Beynon, Rhona A.; Richmond, Rebecca C.; Santos Ferreira, Diana L.; Ness, Andrew R.; May, Margaret; Davey Smith, George; Vincent, Emma E.; Adams, Charleen; Ala-Korpela, Mika; Würtz, Peter; Soidinsalo, Sebastian; Metcalfe, Christopher; Donovan, Jenny L.; Lane, Athene J.; Martin, Richard M. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Lycopene and green tea consumption have been observationally associated with reduced prostate cancer risk, but the underlying mechanisms have not been fully elucidated. We investigated the effect of factorial randomisation to a 6-month lycopene and green tea dietary advice or supplementation intervention on 159 serum metabolite measures in 128 men with raised PSA levels (but prostate cancer-free), analysed by intention-to-treat. The causal effects of metabolites modified by the intervention on p... 
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KW  - prostate cancer; dietary intervention; lycopene; green tea; Mendelian randomisation; MENDELIAN RANDOMIZATION; GENOME-WIDE; ASSOCIATION; INSTRUMENTS; LOCI; METAANALYSIS; MECHANISMS; PREVENTION; CATECHINS; DESIGN; 3122 Cancers 
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