TY  -  
T1  - Isoflurane produces antidepressant effects and induces TrkB signaling in rodents 
SN  -  /  
UR  - http://hdl.handle.net/10138/217887 
T3  -  
A1  - Antila, Hanna; Ryazantseva, Maria; Popova, Dina; Sipilä, Pia; Guirado, Ramon; Kohtala, Samuel; Yalcin, Ipek; Lindholm, Jesse; Vesa, Liisa; Sato, Vinicius; Cordeira, Joshua; Autio, Henri; Kislin, Mikhail; Rios, Maribel; Joca, Samia; Casarotto, Plinio; Khiroug, Leonard; Lauri, Sari; Taira, Tomi; Castren, Eero; Rantamäki, Tomi 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) rece... 
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OP  -  
KW  - MEDIAL PREFRONTAL CORTEX; NEUROPATHIC PAIN; NEUROTROPHIN RECEPTOR; DEPRESSED-PATIENTS; DENDRITIC SPINES; ANESTHESIA; MICE; HIPPOCAMPUS; INHIBITION; KETAMINE; 3112 Neurosciences 
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ER  -