TY - T1 - Isoflurane produces antidepressant effects and induces TrkB signaling in rodents SN - / UR - http://hdl.handle.net/10138/217887 T3 - A1 - Antila, Hanna; Ryazantseva, Maria; Popova, Dina; Sipilä, Pia; Guirado, Ramon; Kohtala, Samuel; Yalcin, Ipek; Lindholm, Jesse; Vesa, Liisa; Sato, Vinicius; Cordeira, Joshua; Autio, Henri; Kislin, Mikhail; Rios, Maribel; Joca, Samia; Casarotto, Plinio; Khiroug, Leonard; Lauri, Sari; Taira, Tomi; Castren, Eero; Rantamäki, Tomi A2 - PB - Y1 - 2017 LA - eng AB - A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) rece... VO - IS - SP - OP - KW - MEDIAL PREFRONTAL CORTEX; NEUROPATHIC PAIN; NEUROTROPHIN RECEPTOR; DEPRESSED-PATIENTS; DENDRITIC SPINES; ANESTHESIA; MICE; HIPPOCAMPUS; INHIBITION; KETAMINE; 3112 Neurosciences N1 - PP - ER -