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T1  - Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression : Role of MAPK signaling pathway 
SN  -  /  
UR  - http://hdl.handle.net/10138/327666 
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A1  - Humo, Muris; Ayazgok, Beyza; Becker, Lea J.; Waltisperger, Elisabeth; Rantamäki, Tomi; Yalcin, Ipek 
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Y1  - 2020 
LA  - eng 
AB  - Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socio-economic burden and result in disability affecting millions of individuals, which urges the development of treatment strategies targeting this comorbidity. Ketamine, a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, is shown to be efficient in treating both pain and depression-related symptoms. However, the molecul... 
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KW  - Ketamine; Neuropathic pain-induced depression; Comorbidity; Anterior cingulate cortex; MKP-1; pERK; ANTERIOR CINGULATE CORTEX; PROTEIN-KINASE PHOSPHATASE-1; NMDA RECEPTOR BLOCKADE; NEUROPATHIC PAIN; PHARMACOLOGICAL-TREATMENT; RAT MODEL; ACTIVATION; MECHANISMS; EXPRESSION; BEHAVIORS; 3112 Neurosciences; 317 Pharmacy 
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