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T1  - Key role of local acetaldehyde in upper GI tract carcinogenesis 
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UR  - http://hdl.handle.net/10138/298233 
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A1  - Salaspuro, Mikko 
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Y1  - 2017 
LA  - eng 
AB  - Ethanol is neither genotoxic nor mutagenic. Its first metabolite acetaldehyde, however, is a powerful local carcinogen. Point mutation in ALDH2 gene proves the causal relationship between acetaldehyde and upper digestive tract cancer in humans. Salivary acetaldehyde concentration and exposure time are the two major and quantifiable factors regulating the degree of local acetaldehyde exposure in the ideal target organ, oropharynx. Instant microbial acetaldehyde formation from alcohol represents >... 
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KW  - Acetaldehyde; Alcohol; ALDH2; Cancer; Cancer risk assessment; Ethanol; Fermented food; L-cysteine; Mouth; Oesophagus; Oropharynx; Pharynx; Stomach; Tobacco; ALDEHYDE DEHYDROGENASE 2; CHRONIC ATROPHIC GASTRITIS; UPPER AERODIGESTIVE TRACT; SQUAMOUS-CELL CARCINOMA; ORAL-CAVITY CANCER; SALIVARY ACETALDEHYDE; ALCOHOL-DEHYDROGENASE; ESOPHAGEAL CANCER; HELICOBACTER-PYLORI; HEAVY DRINKERS; Acetaldehyde; Alcohol; ALDH2; Cancer; Cancer risk assessment; Ethanol; Fermented food; L-cysteine; Mouth; Oesophagus; Oropharynx; Pharynx; Stomach; Tobacco; 3111 Biomedicine 
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