TY - T1 - Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans SN - / UR - http://hdl.handle.net/10138/159778 T3 - A1 - Adiels, Martin; Mardinoglu, Adil; Taskinen, Marja-Riitta; Boren, Jan A2 - PB - Y1 - 2015 LA - eng AB - To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mech... VO - IS - SP - OP - KW - very low density lipoproteins; apoB; multocomnpartmental modeling; kinetics; stable isotopes; LOW-DENSITY LIPOPROTEINS; FATTY LIVER-DISEASE; A-I KINETICS; HEPARAN-SULFATE PROTEOGLYCANS; TYPE-2 DIABETIC MEN; APOLIPOPROTEIN B-100; NONALCOHOLIC STEATOHEPATITIS; MULTICOMPARTMENTAL MODEL; POSTPRANDIAL STATE; INSULIN-RESISTANCE; 3111 Biomedicine N1 - PP - ER -