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T1  - LDL-cholesterol transport to the endoplasmic reticulum : current concepts 
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UR  - http://hdl.handle.net/10138/164492 
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A1  - Pfisterer, Simon G.; Peranen, Johan; Ikonen, Elina 
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Y1  - 2016 
LA  - eng 
AB  - Purpose of review In this article, we summarize the present information related to the export of LDL-derived cholesterol from late endosomes, with a focus on Nieman-Pick disease, type C1 (NPC1) cholesterol delivery toward the endoplasmic reticulum (ER). We review data suggesting that several pathways may operate in parallel, including membrane transport routes and membrane contact sites (MCSs). Recent findings There is increasing appreciation that MCSs provide an important mechanism for intermem... 
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KW  - lipid transfer; membrane contact site; membrane transport; sterol-binding protein; MEMBRANE CONTACT SITES; PLASMA-MEMBRANE; LATE ENDOSOMES; STEROL MOVEMENT; MAMMALIAN-CELLS; ER; TRAFFICKING; PROTEINS; ORGANELLES; NPC1; 1182 Biochemistry, cell and molecular biology; 3111 Biomedicine 
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