TY  -  
T1  - Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs 
SN  -  /  
UR  - http://hdl.handle.net/10138/336965 
T3  -  
A1  - Tayem, Raneem; Niemann, Catherin; Pesch, Monika; Morgner, Jessica; Niessen, Carien M.; Wickström, Sara A.; Aumailley, Monique 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - The skin epidermis is attached to the underlying dermis by a laminin 332 (Lm332)-rich basement membrane. Consequently, loss of Lm332 leads to the severe blistering disorder epidermolysis bullosa junctionalis in humans and animals. Owing to the indispensable role of Lm332 in keratinocyte adhesion in vivo, the severity of the disease has limited research into other functions of the protein. We have conditionally disrupted Lm332 expression in basal keratinocytes of adult mice. Although blisters dev... 
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KW  - ALPHA-6-BETA-4 INTEGRIN; EPIDERMOLYSIS-BULLOSA; TARGETED DISRUPTION; MOLECULAR-BASIS; HAIR FOLLICLE; LAMA3 GENE; KERATINOCYTES; ADHESION; BETA; ALPHA-3-BETA-1; 3121 General medicine, internal medicine and other clinical medicine 
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ER  -