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T1  - Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/167555 
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A1  - Kanninen, Liisa K.; Harjumäki, Riina; Peltoniemi, Pasi; Bogacheva, Mariia S.; Salmi, Tuuli; Porola, Pauliina; Niklander, Johanna; Smutny, Tomas; Urtti, Arto; Yliperttula, Marjo L.; Lou, Yan-Ru 
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Y1  - 2016 
LA  - eng 
AB  - Human pluripotent stem cells (hPSCs) have gained a solid foothold in basic research and drug industry as they can be used in vitro to study human development and have potential to offer limitless supply of various somatic cell types needed in drug development. Although the hepatic differentiation of hPSCs has been extensively studied, only a little attention has been paid to the role of the extracellular matrix. In this study we used laminin-511, laminin-521, and fibronectin, found in human live... 
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KW  - Extracellular matrix; Human embryonic stem cell; Human induced pluripotent stem cell; Hepatic differentiation; Laminin-511; Laminin-521; HEPATOCYTE-LIKE CELLS; HUMAN FETAL HEPATOCYTES; PREGNANE X RECEPTOR; LONG-TERM CULTURE; EXTRACELLULAR-MATRIX; HUMAN LIVER; SELF-RENEWAL; CYTOCHROME-P450 ENZYMES; DIRECT DIFFERENTIATION; DEFINITIVE ENDODERM; 318 Medical biotechnology; 317 Pharmacy 
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