TY  -  
T1  - Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster 
SN  -  /  
UR  - http://hdl.handle.net/10138/305408 
T3  -  
A1  - Salminen, Tiina S.; Cannino, Giuseppe; Oliveira, Marcos T.; Lillsunde, Päivi; Jacobs, Howard T.; Kaguni, Laurie S. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). Here we tested whether any of four natural mtDNA variants was able to modify the effect of the phenotypically mild, nuclear tko(25t) mutation, affecting mitochondrial protein synthesis. When combined with tko(25t), the mtDNA from wild strain KSA2 produced pupal lethality, accompanied by the presence of melanotic nodules in L3 larvae. KSA2 mtDNA, which carries ... 
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IS  -  
SP  -  
OP  -  
KW  - cybrid; respiration; cytochrome b; mtDNA copy number; melanotic nodules; CYTOPLASMIC MALE-STERILITY; INCOMPATIBILITY; PHENOTYPE; MUTATION; DNA; RESISTANCE; DISEASE; LOCUS; MODEL; REPLACEMENT; 1184 Genetics, developmental biology, physiology 
N1  -   
PP  -  
ER  -