TY - T1 - Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation SN - / UR - http://hdl.handle.net/10138/163943 T3 - A1 - Salmenkari, Hanne; Issakainen, Tomi; Vapaatalo, Heikki; Korpela, Riitta A2 - PB - Y1 - 2015 LA - eng AB - AIM: To investigate local corticosterone production and angiotensin- I converting enzyme (ACE) protein expression and their interaction in healthy and inflamed intestine. METHODS: Acute intestinal inflammation was induced to six weeks old male Balb/c mice by administration of either 3% or 5% dextran sodium sulfate (DSS) in drinking water for 7 d (n = 12 in each group). Healthy controls (n = 12) were given tap water. Corticosterone production and ACE protein shedding were measured from ex vivo in... VO - IS - SP - OP - KW - Dextran sodium sulfate; Inflammation; Angiotensin-I converting enzyme; Local corticosterone; Intestine; GLUCOCORTICOID SYNTHESIS; IMMUNOHISTOCHEMICAL LOCALIZATION; CELLS; RECEPTOR; SYSTEM; ACE2; ENDOTHELIUM; EXPRESSION; MEMBRANE; PROTEIN; 3111 Biomedicine; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -