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T1  - Local ocular renin-angiotensin-aldosterone system : any connection with intraocular pressure? A comprehensive review 
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UR  - http://hdl.handle.net/10138/318875 
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A1  - Holappa, Mervi; Vapaatalo, Heikki; Vaajanen, Anu 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - The renin-angiotensin system (RAS) is one of the oldest and most extensively studied human peptide cascades, well-known for its role in regulating blood pressure. When aldosterone is included, RAAS is involved also in fluid and electrolyte homeostasis. There are two main axes of RAAS: (1) Angiotensin (1-7), angiotensin converting enzyme 2 and Mas receptor (ACE2-Ang(1-7)-MasR), (2) Angiotensin II, angiotensin converting enzyme 1 and angiotensin II type 1 receptor (ACE1-AngII-AT1R). In its entiret... 
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KW  - ACE1; ACE2; angiotensin II; angiotensin (1-7); angiotensin receptors; Mas receptor; aldosterone; mineralocorticoid receptor; glaucoma; intraocular pressure; CONVERTING-ENZYME-INHIBITOR; ENDOTOXIN-INDUCED UVEITIS; AQUEOUS-HUMOR OUTFLOW; OPEN-ANGLE GLAUCOMA; TYPE-1 RECEPTOR BLOCKER; II SIGNAL-TRANSDUCTION; UVEOSCLERAL OUTFLOW; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; CHRONIC MODELS; AT1 RECEPTOR; 3125 Otorhinolaryngology, ophthalmology 
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