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T1  - Long-term antipsychotic and benzodiazepine use. and brain volume changes in schizophrenia : The Northern Finland Birth Cohort 1966 study 
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UR  - http://hdl.handle.net/10138/298050 
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A1  - Huhtaniska, Sanna; Jaaskelainen, Erika; Heikka, Tuomas; Moilanen, Jani S.; Lehtiniemi, Heli; Tohka, Jussi; Manjon, Jose V.; Coupe, Pierrick; Bjornholm, Lassi; Koponen, Hannu; Veijola, Juha; Isohanni, Matti; Kiviniemi, Vesa; Murray, Graham K.; Miettunen, Jouko 
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Y1  - 2017 
LA  - eng 
AB  - High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 1... 
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KW  - Schizophrenia; Antipsychotics; Benzodiazepines; Brain; MRI; CEREBRAL VENTRICULAR SIZE; NERVE GROWTH-FACTOR; FOLLOW-UP MRI; LONGITUDINAL MRI; COGNITIVE IMPAIRMENT; CHOLINERGIC NEURONS; ORAL HALOPERIDOL; MACAQUE MONKEYS; BASAL GANGLIA; MEDICATION; 3124 Neurology and psychiatry; 3112 Neurosciences 
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