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T1  - Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons 
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UR  - http://hdl.handle.net/10138/318336 
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A1  - Mavrovic, Martina; Uvarov, Pavel; Delpire, Eric; Vutskits, Laszlo; Kaila, Kai; Puskarjov, Martin 
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Y1  - 2020 
LA  - eng 
AB  - KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl-) extruder critical for hyperpolarizing GABA(A) receptor currents. Independently of its canonical function as a K-Cl cotransporter, KCC2 regulates the actin cytoskeleton via molecular interactions mediated through its large intracellular C-terminal domain (CTD). Contrary to the common assumption that embryonic neocortical projection neurons express KCC2 at non-signif... 
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KW  - CL-COTRANSPORTER KCC2; EXPRESSION; EXTRUSION; GABA; HIPPOCAMPAL-NEURONS; IN-VIVO; KCC2; MATURATION; NEURAL DEVELOPMENT; OHTAHARA SYNDROME; PROGRAMMED CELL-DEATH; cell death; chloride; cofilin; 1182 Biochemistry, cell and molecular biology 
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ER  -