TY  -  
T1  - Loss of the Hematopoietic Stem Cell Factor GATA2 in the Osteogenic Lineage Impairs Trabecularization and Mechanical Strength of Bone 
SN  -  /  
UR  - http://hdl.handle.net/10138/238981 
T3  -  
A1  - Tolkachov, Alexander; Fischer, Cornelius; Ambrosi, Thomas H.; Bothe, Melissa; Han, Chung-Ting; Muenzner, Matthias; Mathia, Susanne; Salminen, Marjo; Seifert, Georg; Thiele, Mario; Duda, Georg N.; Meijsing, Sebastiaan H.; Sauer, Sascha; Schulz, Tim J.; Schupp, Michael 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - The transcription factor GATA2 is required for expansion and differentiation of hematopoietic stem cells (HSCs). In mesenchymal stem cells (MSCs), GATA2 blocks adipogenesis, but its biological relevance and underlying genomic events are unknown. We report a dual function of GATA2 in bone homeostasis. GATA2 in MSCs binds near genes involved in skeletal system development and colocalizes with motifs for FOX and HOX transcription factors, known regulators of skeletal development. Ectopic GATA2 bloc... 
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IS  -  
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OP  -  
KW  - GATA2; bone; cell differentiation; mesenchymal stem cell; osteoblast; trabecularization; ACTIVATED RECEPTOR-GAMMA; TRANSCRIPTION FACTOR GATA-2; LARGE GENE LISTS; ADIPOCYTE DIFFERENTIATION; REGULATES DIFFERENTIATION; OSTEOCLAST DEVELOPMENT; CONTROL ADIPOGENESIS; BROWN ADIPOCYTES; CRE RECOMBINASE; DEFICIENT MICE; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -