TY  -  
T1  - Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export 
SN  -  /  
UR  - http://hdl.handle.net/10138/306337 
T3  -  
A1  - Heybrock, Saskia; Kanerva, Kristiina; Meng, Ying; Ing, Chris; Liang, Anna; Xiong, Zi-Jian; Weng, Xialian; Kim, Young Ah; Collins, Richard; Trimble, William; Pomes, Regis; Prive, Gilbert G.; Annaert, Wim; Schwake, Michael; Heeren, Joerg; Lullmann-Rauch, Renate; Grinstein, Sergio; Ikonen, Elina; Saftig, Paul; Neculai, Dante 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1 that mediates lipid transfer. The detection of cholesterol within the LIMP-2 structure and the formation of cholesterol - like inclusions in LIMP-2 knockout mice suggested the possibility that LIMP2 transports cholesterol in lysosomes. We presen... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - MOLECULAR-DYNAMICS; DENSITY-LIPOPROTEIN; TRANSPORT; RECEPTOR; MECHANISMS; NPC1; CELL; TRAFFICKING; DEGRADATION; DEFICIENCY; 3111 Biomedicine 
N1  -   
PP  -  
ER  -