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T1  - MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone 
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UR  - http://hdl.handle.net/10138/333311 
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A1  - Nam, Jinhan; Koppinen, Tapani K.; Voutilainen, Merja H. 
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Y1  - 2021 
LA  - eng 
AB  - Multiple sclerosis (MS) is a progressive autoimmune disease characterized by T-cell mediated demyelination in central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a widely used in vivo disease model of MS. Glucocorticoids such as dexamethasone (dex) function as immunosuppressants and are commonly used to treat acute exacerbations of MS. Dex is also often used as a positive control in EAE studies, as it has been shown to promote motor behavior, inhibit immune cell infi... 
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KW  - MS; EAE; MANF; dexamethasone; neuroinflammation; UPR; Reactive glia; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ENDOPLASMIC-RETICULUM STRESS; MULTIPLE-SCLEROSIS; NEUROTROPHIC FACTOR; EXPERIMENTAL-MODELS; ER STRESS; LESIONS; GLUCOCORTICOIDS; PREVENTION; MODULATOR; 3112 Neurosciences 
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