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T1  - MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system 
SN  -  /  
UR  - http://hdl.handle.net/10138/318508 
T3  -  
A1  - Pakarinen, Emmi; Danilova, Tatiana; Voikar, Vootele; Chmielarz, Piotr; Piepponen, Petteri; Airavaara, Mikko; Saarma, Mart; Lindahl, Maria 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) localized protein that regulates ER homeostasis and unfolded protein response (UPR). The biology of endogenous MANF in the mammalian brain is unknown and therefore we studied the brain phenotype of MANF-deficient female and male mice at different ages focusing on the midbrain dopamine system and cortical neurons. We show that a lack of MANF from the brain led to the chronic activation of UPR by upregulati... 
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KW  - ALZHEIMERS-DISEASE; CNS; ENDOPLASMIC-RETICULUM STRESS; ER STRESS; ER stress; GENE; IMMUNOREACTIVITY; KAPPA-B; MANF; NERVOUS-SYSTEM; NEUROTROPHIC FACTOR MANF; PARKINSONS-DISEASE; UNFOLDED PROTEIN RESPONSE; dopamine; knock-out mice; unfolded protein response; 3112 Neurosciences 
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