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T1  - MAPK/ERK Signaling in Regulation of Renal Differentiation 
SN  -  /  
UR  - http://hdl.handle.net/10138/301873 
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A1  - Kurtzeborn, Kristen; Kwon, Hyuk Nam; Kuure, Satu 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branchi... 
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KW  - extracellular signal-regulated kinase; MAPK; ERK signaling; intracellular signaling; kidney development; ureteric bud branching morphogenesis; nephrogenesis; progenitor cells; self-renewal; differentiation; ACTIVATED PROTEIN-KINASE; NEPHRON PROGENITOR CELLS; URETERAL BUD OUTGROWTH; P38 MAP KINASE; BRANCHING MORPHOGENESIS; MICE LACKING; KIDNEY DEVELOPMENT; NEUROTROPHIC FACTOR; MAMMALIAN KIDNEY; GENE-EXPRESSION; 1182 Biochemistry, cell and molecular biology; 116 Chemical sciences 
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ER  -