TY - T1 - MITOCHONDRIAL DNA REPLICATION DEFECTS : CONSEQUENCES FOR NEONATAL HEART DISEASE & PREMATURE AGEING SN - / UR - URN:ISBN:978-951-51-8097-1; http://hdl.handle.net/10138/343100 T3 - A1 - Landoni Martin, Juan Cruz A2 - PB - Helsingin yliopisto Y1 - 2022 LA - en AB - Mitochondria are organelles crucially involved in energy metabolism (hence the “powerhouses of the cell”) and most other cellular processes. They accommodate the second essential genome of the human cell: mitochondrial DNA (mtDNA). The integrity and quantity of mitochondrial genomes, as well as the systems in charge of its maintenance, have been associated with a wide variety of rare and common human diseases, as well as ageing. The causes behind such striking diversity in presentation remain la... VO - IS - SP - OP - KW - mitochondrial Medicine - Integrative Life Sciences N1 - PP - ER -