TY  -  
T1  - MYC-Induced miR-203b-3p and miR-203a-3p Control Bc1-xL Expression and Paclitaxel Sensitivity in Tumor Cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/287674 
T3  -  
A1  - Aakko, Sofia; Straume, Anne Hege; Birkeland, Einar Elvbakken; Chen, Ping; Qiao, Xi; Lonning, Per Eystein; Kallio, Marko J. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent therapy responses, and the molecular determinants of taxane sensitivity have remained elusive. Especially the signaling pathways that promote death of the taxane-treated cells are poorly characterized. Here we describe a novel part of a signaling route in which c-Myc enhances paclitaxel sensitivity through upregulation of miR-203b-3p and mi... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - BCL-X-L; INDUCED APOPTOSIS; C-MYC; BREAST; MICRORNA; MICROTUBULES; CHEMOTHERAPY; INHIBITION; REPRESSION; MIRNA; 3122 Cancers 
N1  -   
PP  -  
ER  -