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T1  - MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures 
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UR  - http://hdl.handle.net/10138/161028 
T3  -  
A1  - Haikala, Heidi M.; Klefstrom, Juha; Eilers, Martin; Wiese, Katrin E. 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Apoptosis caused by deregulated MYC expression is a prototype example of intrinsic tumor suppression. However, it is still unclear how supraphysiological MYC expression levels engage specific sets of target genes to promote apoptosis. Recently, we demonstrated that repression of SRF target genes by MYC/MIZ1 complexes limits AKT-dependent survival signaling and contributes to apoptosis induction. Here we report that supraphysiological levels of MYC repress gene sets that include markers of basal-... 
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KW  - MIZ1; mammary epithelial cells; lineage fate; repression; MYC; apoptosis; C-MYC; TRANSGENIC MICE; BREAST-CANCER; STEM-CELLS; INDUCED TUMORIGENESIS; ONCOGENIC PROPERTIES; EXPRESSION; GLAND; DIFFERENTIATION; ACTIVATION; 3111 Biomedicine 
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PP  -  
ER  -