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T1  - Mast cells and complement system: Ancient interactions between components of innate immunity 
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UR  - http://hdl.handle.net/10138/322169 
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A1  - Elieh Ali Komi, Daniel; Shafaghat, Farzaneh; Kovanen, Petri T.; Meri, Seppo 
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Y1  - 2020 
LA  - eng 
AB  - Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules. The system's main biological functions include lysis, opsonization, and recruitment of phagocytes. MCs, beyond their classic role as master cells of allerg... 
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KW  - 3111 Biomedicine; C3aR; C5aR; inflammation; innate immunity; urticaria; ACTIVATION; PHAGOCYTOSIS; PROTEIN; PHOSPHORYLATION; RECEPTOR; FACTOR C5A; C3A; DISEASE; A-BETA; ANAPHYLATOXINS 
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