TY - T1 - Mathematical models on the impact of noise and dyadic molecular structures on the properties of a cardiac myocyte SN - / UR - URN:ISBN:978-952-10-4653-7; http://hdl.handle.net/10138/21279 T3 - A1 - Tanskanen, Antti A2 - PB - Helsingin yliopisto Y1 - 2008 LA - en AB - In cardiac myocytes (heart muscle cells), coupling of electric signal known as the action potential to contraction of the heart depends crucially on calcium-induced calcium release (CICR) in a microdomain known as the dyad. During CICR, the peak number of free calcium ions (Ca) present in the dyad is small, typically estimated to be within range 1-100. Since the free Ca ions mediate CICR, noise in Ca signaling due to the small number of free calcium ions influences Excitation-Contraction (EC) co... VO - IS - SP - OP - KW - sovellettu matematiikka N1 - PP - ER -