TY - T1 - Matrix Metalloproteinases-8 and-9 and Tissue Inhibitor of Metalloproteinase-1 in Burn Patients. A Prospective Observational Study SN - / UR - http://hdl.handle.net/10138/157015 T3 - A1 - Hästbacka, Johanna; Freden, Filip; Hult, Maarit; Bergquist, Maria; Wilkman, Erika; Vuola, Jyrki; Sorsa, Timo; Tervahartiala, Taina; Huss, Fredrik A2 - PB - Y1 - 2015 LA - eng AB - Introduction Matrix metalloproteinases (MMPs) -8 and -9 are released from neutrophils in acute inflammation and may contribute to permeability changes in burn injury. In retrospective studies on sepsis, levels of MMP-8, MMP-9, and tissue inhibitor of metalloproteinase-1 (TIMP-1) differed from those of healthy controls, and TIMP-1 showed an association with outcome. Our objective was to investigate the relationship between these proteins and disease severity and outcome in burn patients. Methods ... VO - IS - SP - OP - KW - CRITICALLY-ILL PATIENTS; SEVERE SEPSIS; GELATINASE B; EXPRESSION; TIMP-1; COLLAGENASE; INJURY; CELLS; SERUM; MATRIX-METALLOPROTEINASE-9; 3126 Surgery, anesthesiology, intensive care, radiology; 313 Dentistry N1 - PP - ER -