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T1  - Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life 
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UR  - http://hdl.handle.net/10138/307596 
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A1  - Ruohtula, Terhi; de Goffau, Marcus C.; Nieminen, Janne K.; Honkanen, Jarno; Siljander, Heli; Hämäläinen, Anu-Maaria; Peet, Aleksandr; Tillmann, Vallo; Ilonen, Jorma; Niemelä, Onni; Welling, Gjalt W.; Knip, Mikael; Harmsen, Hermie J.; Vaarala, Outi 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Estonian and Finnish children followed from 3 to 36 months of age. We describe here an infant Treg phenotype characterized by high Treg frequency, the maturation of Treg population chara... 
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KW  - regulatory T-cells; bifidobacteria; gut microbiome; atopic diseases; IgE; INTESTINAL MICROFLORA; CHILDHOOD; FOXP3; BUTYRATE; DIFFERENTIATION; ASTHMA; METABOLITES; PREVALENCE; PROMOTES; BARRIER; 3121 General medicine, internal medicine and other clinical medicine 
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