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T1  - Maturation of Oxycodone Pharmacokinetics in Neonates and Infants : a Population Pharmacokinetic Model of Three Clinical Trials 
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UR  - http://hdl.handle.net/10138/234743 
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A1  - Valitalo, Pyry; Kokki, Merja; Ranta, Veli-Pekka; Olkkola, Klaus T.; Hooker, Andrew C.; Kokki, Hannu 
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PB  -  
Y1  - 2017 
LA  - eng 
AB  - Purpose The aim of the current population pharmacokinetic study was to quantify oxycodone pharmacokinetics in children ranging from preterm neonates to children up to 7 years of age. Methods Data on intravenous or intramuscular oxycodone administration were obtained from three previously published studies (n = 119). The median [range] postmenstrual age of the subjects was 299 days [170 days-7.8 years]. A population pharmacokinetic model was built using 781 measurements of oxycodone plasma concen... 
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KW  - analgesic; opioid. infant; extremely premature; oxycodone; pain; pharmacokinetics; DEVELOPMENTAL PHARMACOKINETICS; CHILDREN; METABOLITES; MORPHINE; 116 Chemical sciences; 317 Pharmacy 
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