TY - T1 - Mechanical Forces in the Skin : Roles in Tissue Architecture, Stability, and Function SN - / UR - http://hdl.handle.net/10138/317802 T3 - A1 - Biggs, Leah C.; Kim, Christine S.; Miroshnikova, Yekaterina A.; Wickström, Sara A. A2 - PB - Y1 - 2020 LA - eng AB - Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding tissue. Tissue architecture and its dynamic changes subsequently feed back to guide cell behavior. The skin is a dynamic, self-renewing barrier that is subjected to large-scale extrinsic mechanical forces throughout its lifetime. The ability to withstand this constant mechanical stress without compromising its integrity as a barrier requires co... VO - IS - SP - OP - KW - SERUM RESPONSE FACTOR; TERMINAL DIFFERENTIATION; EPIDERMAL BARRIER; BASEMENT-MEMBRANE; FIBROBLAST HETEROGENEITY; ALPHA-6-BETA-4 INTEGRIN; EPIDERMOLYSIS-BULLOSA; TIGHT JUNCTIONS; CELL-ADHESION; ACTIN; 3121 General medicine, internal medicine and other clinical medicine; 3111 Biomedicine N1 - PP - ER -