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T1  - Mechanisms of GDF15 intracellular trafficking 
SN  -  /  
UR  - URN:NBN:fi:hulib-202012094848; http://hdl.handle.net/10138/322556 
T3  -  
A1  - Raza, Shaffaq 
A2  -  
PB  - Helsingin yliopisto 
Y1  - 2020 
LA  - eng 
AB  - Growth differentiation factor 15 (GDF15), a member of TGF-β super family is a soluble cytokine that is associated with different pathological conditions including cancer, cardiac and renal failure and obesity. Its high serum levels are linked with symptoms like cachexia/anorexia in cancer patients and can be used as a marker for these diseases. Its crucial role in weight regulation and energy homeostasis has been demonstrated by treating obese mice with GDF15, which results in weight lose along ... 
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KW  - GDF15; body weight regulation; cancer; Endocytosis; Actin; PI3K activation; GFRAL; RET; Golgi retention; yleinen mikrobiologia; General Microbiology; allmän mikrobiologi 
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