TY - T1 - Mechanistic insights into oncolytic adenovirus therapy SN - / UR - URN:ISBN:978-951-51-8836-6; http://hdl.handle.net/10138/352350 T3 - A1 - Heiniƶ, Camilla A2 - PB - Helsingin yliopisto Y1 - 2023 LA - en AB - The effects of cancer immunotherapy are based on activating and utilizing the immune system to fight cancer cells. In this thesis, a form of immunotherapy, specifically oncolytic adenoviruses, were studied. Immunotherapies are costly to produce and different oncolytic viruses are used in relatively high concentrations and amounts when cancer patients are treated. Thus we wanted to optimize adenovirus vector design, enhance the delivery of adenoviruses to the tumor as well as define and show the ... VO - IS - SP - OP - KW - oncoimmunology N1 - PP - ER -