TY  -  
T1  - Membrane-Dependent Binding and Entry Mechanism of Dopamine into Its Receptor 
SN  -  /  
UR  - http://hdl.handle.net/10138/326578 
T3  -  
A1  - Lolicato, Fabio; Juhola, Hanna; Zak, Agata; Postila, Pekka A.; Saukko, Annina; Rissanen, Sami; Enkavi, Giray; Vattulainen, Ilpo; Kepczynski, Mariusz; Rog, Tomasz 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Synaptic neurotransmission has recently been proposed to function via either a membrane-independent or a membrane-dependent mechanism, depending on the neurotransmitter type. In the membrane-dependent mechanism, amphipathic neurotransmitters first partition to the lipid headgroup region and then diffuse along the membrane plane to their membrane-buried receptors. However, to date, this mechanism has not been demonstrated for any neurotransmitter-receptor complex. Here, we combined isothermal cal... 
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IS  -  
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OP  -  
KW  - synaptic neurotransmission; ligand entry pathway prediction; lipid membrane; molecular dynamics; random acceleration molecular dynamics; umbrella sampling; PARTICLE MESH EWALD; ATOM FORCE-FIELD; MOLECULAR-DYNAMICS; POTENTIAL FUNCTIONS; MELATONIN; AFFINITY; PATHWAYS; CALCIUM; GROMACS; RELEASE; 114 Physical sciences 
N1  -   
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ER  -