TY - T1 - Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection SN - / UR - http://hdl.handle.net/10138/240369 T3 - A1 - Azinas, S.; Bano, F.; Torca, I.; Bamford, D. H.; Schwartz, G. A.; Esnaola, J.; Oksanen, H. M.; Richter, R. P.; Abrescia, N. G. A2 - PB - Y1 - 2018 LA - eng AB - The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provi... VO - IS - SP - OP - KW - ATOMIC-FORCE MICROSCOPY; BACTERIOPHAGE PRD1; HUMAN ADENOVIRUS; WILD-TYPE; PROTEIN; DNA; CAPSIDS; PHAGE; REINFORCEMENT; QUANTITATION; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -