TY  -  
T1  - Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD 
SN  -  /  
UR  - http://hdl.handle.net/10138/313531 
T3  -  
A1  - Hyvärinen, Kati; Koskela, Satu; Niittyvuopio, Riitta; Nihtinen, Anne; Volin, Liisa; Salmenniemi, Urpu; Putkonen, Mervi; Buño, Ismael; Gallardo, David; Itälä-Remes, Maija; Partanen, Jukka; Ritari, Jarmo 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Graft-vs.-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation that causes mortality and severe morbidity. Genetic disparities in human leukocyte antigens between the recipient and donor are known contributors to the risk of the disease. However, the overall impact of genetic component is complex, and consistent findings across different populations and studies remain sparse. To gain a comprehensive understanding of the genes responsible for GvHD, ... 
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KW  - 1182 Biochemistry, cell and molecular biology; GvHD; GWAS; gene expression; meta-analysis; HSCT; VERSUS-HOST-DISEASE; MINOR HISTOCOMPATIBILITY ANTIGENS; SINGLE NUCLEOTIDE POLYMORPHISMS; CHRONIC GRAFT; TRANSPLANTATION; RECEPTOR; SUSCEPTIBILITY; METABOLISM; ACTIVATION; PROFILES 
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