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T1  - Metabolic milieu associates with impaired skeletal characteristics in obesity 
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UR  - http://hdl.handle.net/10138/203754 
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A1  - Viljakainen, Heli T.; Koistinen, Heikki A.; Tervahartiala, Taina; Sorsa, Timo; Andersson, Sture; Mäkitie, Outi 
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Y1  - 2017 
LA  - eng 
AB  - High leptin concentration, low-grade inflammation, and insulin resistance often coexist in obese subjects; this adverse metabolic milieu may be the main culprit for increased fracture risk and impaired bone quality seen in patients with type 2 diabetes. We examined the associations of leptin, hs (high sensitivity)-CRP and insulin resistance with bone turnover markers (BTMs) and bone characteristics in 55 young obese adults (median BMI 40 kg/m(2)) and 65 non-obese controls. Mean age of the subjec... 
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KW  - C-REACTIVE PROTEIN; BONE-MINERAL DENSITY; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; POSTMENOPAUSAL WOMEN; FRACTURE RISK; INFLAMMATION; TURNOVER; LEPTIN; 3121 General medicine, internal medicine and other clinical medicine; 3123 Gynaecology and paediatrics 
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