TY  -  
T1  - Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/247816 
T3  -  
A1  - Tigistu-Sahle, Feven; Lampinen, Milla; Kilpinen, Lotta; Holopainen, Minna; Lehenkari, Petri; Laitinen, Saara; Käkelä, Reijo 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - High arachidonic acid (20:4n-6) and low n-3 PUFA levels impair the capacity of cultured human bone marrow mesenchymal stromal cells (hBMSCs) to modulate immune functions. The capacity of the hBMSCs to modify PUFA structures was found to be limited. Therefore, different PUFA supplements given to the cells resulted in very different glycerophospholipid (GPL) species profiles and substrate availability for phospholipases, which have preferences for polar head group and acyl chains when liberating P... 
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IS  -  
SP  -  
OP  -  
KW  - arachidonic acid; docosahexaenoic acid; eicosapentaenoic acid; glycerophospholipid; immunomodulation; lipid signaling; mass spectrometry; mesenchymal stromal/stem cell; prostaglandin E2; TANDEM MASS-SPECTROMETRY; HEMATOPOIETIC STEM-CELLS; PROTEIN-KINASE-C; ARACHIDONIC-ACID; PROGENITOR CELLS; LIPID RAFTS; ELECTROSPRAY-IONIZATION; INFLAMMATORY CELLS; NITRIC-OXIDE; RAT-LIVER; 1182 Biochemistry, cell and molecular biology 
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ER  -