TY  -  
T1  - Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes 
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UR  - http://hdl.handle.net/10138/224629 
T3  -  
A1  - Puhka, Maija; Takatalo, Maarit; Nordberg, Maria-Elisa; Valkonen, Sami; Nandania, Jatin; Aatonen, Maria; Yliperttula, Marjo; Laitinen, Saara; Velagapudi, Vidya; Mirtti, Tuomas; Kallioniemi, Olli; Rannikko, Antti; Siljander, Pia R-M; Af Hallstrom, Taija Maria 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from the secreting cells. So far, biomarkers for pathological conditions have been mainly searched from their protein, (mi) RNA, DNA and lipid cargo. Here, we explored the small molecule metabolites from urinary and platelet EVs relative to their matched source samples. As a proof-of-concept study of intra-EV metabolites, we compared alternative normalization methods to profile urinary EVs from prostate canc... 
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IS  -  
SP  -  
OP  -  
KW  - extracellular vesicles; exosomes; metabolomics; urine; platelets; prostate cancer; HUMAN URINARY EXOSOMES; BIOMARKER DISCOVERY; HYALURONAN; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology; 317 Pharmacy 
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ER  -