TY  -  
T1  - Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation 
SN  -  /  
UR  - http://hdl.handle.net/10138/160536 
T3  -  
A1  - Meakin, Paul J.; Morrison, Vicky L.; Sneddon, Claire C.; Savinko, Terhi; Uotila, Liisa; Jalicy, Susan M.; Gabriel, Jennie L.; Kang, Li; Ashford, Michael L. J.; Fagerholm, Susanna C. 
A2  -  
PB  -  
Y1  - 2015 
LA  - eng 
AB  - Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their intracellular domain. Here, we investigate the involvement of beta2-integrins in the regulation of metabolic disease using mice where the kindlin-3 binding site in the beta2-integrin cytoplasmic tail has been mutated (TTT/AAA-beta2-integrin knock-in (KI) mice), leading to expressed but dysfunctional beta2-integrins and significant neutrop... 
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IS  -  
SP  -  
OP  -  
KW  - DIET-INDUCED OBESITY; ADHESION RECEPTORS; ADIPOSE-TISSUE; IN-VIVO; CD18; SKIN; METABOLISM; EXPRESSION; ELASTASE; MUSCLE; 1184 Genetics, developmental biology, physiology 
N1  -   
PP  -  
ER  -