TY - T1 - Microstructure analysis method for evaluating degenerated intervertebral disc tissue SN - / UR - http://hdl.handle.net/10138/231344 T3 - A1 - Friedmann, Andrea; Goehre , Felix; Ludtka, Christopher; Mendel, Thomas; Meisel, Hans-Joerg; Heilmann, Andreas; Schwan, Stefan A2 - PB - Y1 - 2017 LA - eng AB - Degeneration of intervertebral disc (IVD) tissue is characterized by several structural changes that result in variations in disc physiology and loss of biomechanical function. The complex process of degeneration exhibits highly intercorrelated biomechanical, biochemical, and cellular interactions. There is currently some understanding of the cellular changes in degenerated intervertebral disc tissue, but microstructural changes and deterioration of the tissue matrix has previously been rarely e... VO - IS - SP - OP - KW - Microstructure; Disc tissue; IDD; Delamination; Cell density; Scanning electron microscopy; SEM; NUCLEUS PULPOSUS; EXTRACELLULAR-MATRIX; MECHANICAL FUNCTION; SURGICAL SPECIMENS; ANULUS FIBROSUS; MOLECULAR-BASIS; CROSS-LINKING; AGE; NEOVASCULARIZATION; SENESCENCE; 3126 Surgery, anesthesiology, intensive care, radiology N1 - PP - ER -