TY - T1 - Modification and development of probiotic strains Saccharomyces boulardii CNCM I-745 and Lacticaseibacillus rhamnosus GG SN - / UR - URN:ISBN:978-951-51-7574-8; http://hdl.handle.net/10138/334770 T3 - A1 - Li, Ran A2 - PB - Helsingin yliopisto Y1 - 2021 LA - en AB - Probiotics are defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host”. In this doctoral dissertation, probiotic strains Saccharomyces boulardii CNCM I-745 and Lacticaseibacillus rhamnosus GG (LGG) were developed as next-generation probiotics. The constructed S. boulardii strains, i.e., SAC4 based on the wild-type S. boulardii CNCM I-745 and SAC12 based on the URA3 auxotrophic derivative, secreted bacteriocin leucocin C, which showed inhi... VO - IS - SP - OP - KW - microbiology N1 - PP - ER -