TY - T1 - Modulation of microglial phagocytosis in vitro SN - / UR - URN:NBN:fi:hulib-202108253497; http://hdl.handle.net/10138/333541 T3 - A1 - Järvinen, Elli Katariina A2 - PB - Helsingin yliopisto Y1 - 2021 LA - eng AB - Ischemic stroke is a complex disease involving multiple pathophysiological mechanisms. To date, many therapeutic intervention strategies such as anti-inflammatory treatments have been tested, but none of them has been successful. Previous studies have shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) improves stroke recovery and increases the expression of phagocytosis related genes. In this study, the phagocytic and inflammatory effect of monocyte chemoattractant protein 1 (... VO - IS - SP - OP - KW - ischemic stroke; microglia; phagocytosis; ER stress; ADGRE1; C3; C3a; MANF; MCP-1; M-CSF; MerTK; Neuroscience and psychobiology; Neuroscience and psychobiology; Neuroscience and psychobiology; Translationaalisen lääketieteen maisteriohjelma (Translational Medicine); Master's Programme in Translational Medicine; Magisterprogrammet i translationell medicin N1 - PP - ER -