TY - T1 - Molecular forms and fragments of salivary MMP-8 in relation to periodontitis SN - / UR - http://hdl.handle.net/10138/306204 T3 - A1 - Gürsoy, Ulvi K.; Könönen, Eija; Tervahartiala, Taina; Gürsoy, Mervi; Pitkänen, Jari; Torvi, Paula; Suominen, Anna-Liisa; Pussinen, Pirkko; Sorsa, Timo A2 - PB - Y1 - 2018 LA - eng AB - Aim To investigate the molecular forms of salivary matrix metalloproteinase (MMP)-8 in relation to periodontitis. Materials and Methods Molecular forms, degree of activation and fragmentation of neutrophilic and mesenchymal-type MMP-8 isoforms were analysed from salivary samples of 81 subjects with generalized periodontitis, 63 subjects with localized periodontitis and 79 subjects without pocket teeth, by using western-immunoblots with computer quantitation. In addition, human recombinant proMMP... VO - IS - SP - OP - KW - collagenase; neutrophil; periodontal disease; saliva; HUMAN NEUTROPHIL COLLAGENASE; GINGIVAL CREVICULAR FLUID; LATENT HUMAN NEUTROPHIL; MATRIX METALLOPROTEINASES; PORPHYROMONAS-GINGIVALIS; ACTIVATION; RELEASE; EXPRESSION; PROTEASES; MARKERS; 313 Dentistry; 3126 Surgery, anesthesiology, intensive care, radiology N1 - PP - ER -