TY - T1 - Morfiinin vaikutukset ehdollistetussa paikkahakuisuuskokeessa AMPA-tyypin glutamaattireseptorin GluA1-alayksikön poistogeenisillä hiirillä SN - / UR - URN:NBN:fi-fe20180115195; http://hdl.handle.net/10138/17172 T3 - A1 - Ojala, Katja A2 - PB - Helsingfors universitet Y1 - 2010 LA - fin AB - Glutamate is the principal excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission plays a central role in the development and maintenance of drug addiction. Glutamate interacts with other neurotransmitters such as dopamine in the actions concerning addiction. During the development of drug addiction, plastic changes in the neuronal connections related to memory and learning occur for example in the amount of synapses and in the efficacy of their action. Glutam... VO - IS - SP - OP - KW - AMPA; addiction; glutamate; knockout mouse; conditioned place preference; locomotor activity; morphine; riippuvuus; glutamaatti; poistogeeninen hiiri; ehdollistettu paikkahakuisuus; morfiini; lokomotorinen aktiivisuus; Farmakologi och toxikologi; Pharmacology and toxicology; Farmakologia ja toksikologia N1 - PP - ER -