TY - T1 - Morphine-induced behavioral sensitization in alcohol-preferring and alcohol-avoiding rat lines SN - / UR - http://hdl.handle.net/10138/229391 T3 - A1 - Ojanen, Sami A2 - PB - Y1 - 2006 LA - eng AB - Repeated use of drugs of abuse induces permanent changes in the brain that together with environmental factors can promote the development of addiction. Addiction to alcohol or drugs is a chronic disease that is characterized by a compulsion to seek and take the drug, loss of control in limiting intake, continued use despite obvious harm, and recurrent relapses. Behavioral animal models of addiction are invaluable tools for evaluating the neuroadaptations underlying these behaviors. Behavioral s... VO - IS - SP - OP - KW - 1184 Genetics, developmental biology, physiology; ethanol; glutamate; GABA; microdialysis; morphine; sensitization N1 - PP - ER -