TY  -  
T1  - Mouse models for human intestinal microbiota research : a critical evaluation 
SN  -  /  
UR  - http://hdl.handle.net/10138/231776 
T3  -  
A1  - Hugenholtz, Floor; de Vos, Willem M. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Since the early days of the intestinal microbiota research, mouse models have been used frequently to study the interaction of microbes with their host. However, to translate the knowledge gained from mouse studies to a human situation, the major spatio-temporal similarities and differences between intestinal microbiota in mice and humans need to be considered. This is done here with specific attention for the comparative physiology of the intestinal tract, the effect of dietary patterns and dif... 
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IS  -  
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OP  -  
KW  - Microbiome; Metagenome; Phylogeny; Murine models; Reproducibility; Diet; SEGMENTED FILAMENTOUS BACTERIA; DISTAL GUT MICROBIOME; DIET-INDUCED OBESITY; GASTROINTESTINAL-TRACT; MUCUS LAYERS; AKKERMANSIA-MUCINIPHILA; COLONIC BIOPSIES; KEY ROLE; MICE; DIVERSITY; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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PP  -  
ER  -