TY - T1 - Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits SN - / UR - http://hdl.handle.net/10138/340836 T3 - A1 - LifeLines Cohort Study; Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Kilpeläinen, Tuomas O. A2 - PB - Y1 - 2021 LA - eng AB - Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to ... VO - IS - SP - OP - KW - blood pressure; depressive symptoms; gene-environment interaction; genome-wide association study; GWAS; GxE; hypertension; psychosocial factors; 3111 Biomedicine N1 - PP - ER -