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T1  - Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits 
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UR  - http://hdl.handle.net/10138/340836 
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A1  - LifeLines Cohort Study; Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Kilpeläinen, Tuomas O. 
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Y1  - 2021 
LA  - eng 
AB  - Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to ... 
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KW  - blood pressure; depressive symptoms; gene-environment interaction; genome-wide association study; GWAS; GxE; hypertension; psychosocial factors; 3111 Biomedicine 
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ER  -