TY - T1 - Multi-locus interactions and the build-up of reproductive isolation SN - / UR - http://hdl.handle.net/10138/323392 T3 - A1 - Satokangas, Ina; Martin, S. H.; Helanterä, H.; Saramaki, J.; Kulmuni, J. A2 - PB - Y1 - 2020 LA - eng AB - All genes interact with other genes, and their additive effects and epistatic interactions affect an organism's phenotype and fitness. Recent theoretical and empirical work has advanced our understanding of the role of multi-locus interactions in speciation. However, relating different models to one another and to empirical observations is challenging. This review focuses on multi-locus interactions that lead to reproductive isolation (RI) through reduced hybrid fitness. We first review theoreti... VO - IS - SP - OP - KW - multi-locus interactions; networks; speciation; reproductive isolation; epistasis; incompatibility; DOBZHANSKY-MULLER INCOMPATIBILITIES; GENOME-WIDE DISSECTION; GENE-EXPRESSION; HYBRID INCOMPATIBILITY; ADAPTIVE INTROGRESSION; DIVERGENT SELECTION; BIOPHYSICAL MODEL; SMALL-WORLD; EVOLUTION; SPECIATION; 1181 Ecology, evolutionary biology N1 - PP - ER -