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T1  - Multigenerational and Transgenerational Effects of Dioxins 
SN  -  /  
UR  - http://hdl.handle.net/10138/304245 
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A1  - Viluksela, Matti; Pohjanvirta, Raimo 
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Y1  - 2019 
LA  - eng 
AB  - Dioxins are ubiquitous and persistent environmental contaminants whose background levels are still reason for concern. There is mounting evidence from both epidemiological and experimental studies that paternal exposure to the most potent congener of dioxins, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can lower the male/female ratio of offspring. Moreover, in laboratory rodents and zebrafish, TCDD exposure of parent animals has been reported to result in reduced reproductive performance along w... 
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KW  - 2; 3; 7; 8-tetrachlorodibenzo-p-dioxin (TCDD); dioxins; aryl hydrocarbon receptor; epigenetic modifications; transgenerational effects; gender ratio; preterm birth; paternal; maternal; ARYL-HYDROCARBON RECEPTOR; SPRAGUE-DAWLEY RATS; BREAST-CANCER CELLS; SEX-RATIO; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; DNA METHYLATION; AH-RECEPTOR; OXIDATIVE STRESS; TRANSCRIPTIONAL SUPPRESSION; SUBCELLULAR-LOCALIZATION; 1182 Biochemistry, cell and molecular biology; 116 Chemical sciences 
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