TY  -  
T1  - Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia – the effects of blocking myostatin and activins 
SN  -  /  
UR  - http://hdl.handle.net/10138/318918 
T3  -  
A1  - Hulmi, Juha J.; Penna, Fabio; Pöllänen, Noora; Nissinen, Tuuli A.; Hentila, Jaakko; Euro, Liliya; Lautaoja, Juulia H.; Ballarò, Riccardo; Soliymani, Rabah; Baumann, Marc; Ritvos, Olli; Pirinen, Eija; Lalowski, Maciej 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an effect on tumour growth. However, the underlying mechanisms are poorly understood. The present study aimed to identify cancer cachexia and soluble ACVR (sACVR) administration-evoked changes in muscle proteome. Methods Healthy and C26 tumour-bearing (T... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 318 Medical biotechnology; C26; OXPHOS; APR; Nrk2; Activin receptor; Cancer cachexia; C26; Cancer cachexia; Activin receptor; Nrk2; APR; OXPHOS; MUSCULAR-DYSTROPHY; EXPRESSION; METABOLISM; SIRTUINS; REVERSAL; MICE 
N1  -   
PP  -  
ER  -