TY  -  
T1  - Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia 
SN  -  /  
UR  - http://hdl.handle.net/10138/313020 
T3  -  
A1  - Awad, Shady Adnan; Kankainen, Matti; Ojala, Teija; Koskenvesa, Perttu; Eldfors, Samuli; Ghimire, Bishwa; Kumar, Ashwini; Kytölä, Soili; Kamel, Mahmoud M.; Heckman, Caroline A.; Porkka, Kimmo; Mustjoki, Satu 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm accounting for similar to 15% of all leukemia. Progress of the disease from an indolent chronic phase to the more aggressive accelerated phase or blast phase (BP) occurs in a minority of cases and is associated with an accumulation of somatic mutations. We performed genetic profiling of 85 samples and transcriptome profiling of 12 samples from 59 CML patients. We identified recurrent somatic mutations in ABL1 (37%), ASXL1 (26%), RUN... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - PROTEIN-TYROSINE PHOSPHATASES; DNA-DAMAGE RESPONSE; MISMATCH REPAIR; STEM; REACTIVATION; EXPRESSION; CELLS; RECOMBINATION; SIGNATURES; NEOPLASMS; 3122 Cancers 
N1  -   
PP  -  
ER  -