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T1  - Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/311282 
T3  -  
A1  - Poon, W. L.; Alenius, Harri; Ndika, Joseph; Fortino, Vittorio; Kolhinen, Vesa; Mesceriakovas, Arunas; Wang, Mingfu; Greco, Dario; Lähde, Anna; Jokiniemi, Jorma; Lee, Jetty Chung-Yung; El-Nezami, Hani; Karisola, Piia 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Nano-sized metal oxides are currently the most manufactured nanomaterials (NMs), and are increasingly used in consumer products. Recent exposure data reveal a genuine potential for adverse health outcomes for a vast array of NMs, however the underlying mechanisms are not fully understood. To elucidate size-related molecular effects, differentiated THP-1 cells were exposed to nano-sized materials (n-TiO2, n-ZnO and n-Ag), or their bulk-sized (b-ZnO and b-TiO2) or ionic (i-Ag) counterparts, and ge... 
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IS  -  
SP  -  
OP  -  
KW  - ZnO; Ag; nanomaterials; immune system; transcriptomics; INFLAMMASOME ACTIVATION; NALP3 INFLAMMASOME; NANOPARTICLES; NANOMATERIALS; MONOCYTES; TOXICITY; IFIT1; 3111 Biomedicine 
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